Epub 2020 Aug 29. Oral candidiasis, altered taste, dysphonia, hoarseness. Therefore, the aim of this study was to prepare and evaluate the microparticles intended to mask a bitter taste of the prednisolone and use … 2011 May;8(5):665-75. doi: 10.1517/17425247.2011.566553. & Terms of Use. June 3, 2011 at 10:45 am; 7 replies; TODO: Email modal placeholder. doi: 10.1371/journal.pone.0244646. 2465-2467, the disclosure of both are herein incorporated by reference. Parabens are preferred, with methylparaben most preferred for use as preservative ingredients to add to the present pharmaceutical solution, although other pharmaceutically acceptable preservatives may be substituted therefor. You have about a 30-40% chance of getting it back. What a relief Pharmaceutics. From what I've read, once you've made it to the 2nd trimester your body accepts the baby, rather than sees it as a threat, so the NK cells don't attack it. This will help remove the bitter taste and make taking the medicine much easier. Right now I have the medicine sitting in chocolate milk with chocolate syrup and I can even taste it. Rash — if the inhaled corticosteroid is administered through a face mask or nebulizer a steroid rash (reddening and atrophy) may develop on the nose and around the mouth. Microparticles based on the Eudragit E PO or E 100 as a taste-masking agent were prepared with spray-drying technique. The present invention addresses this and other needs. Yes it is a liquid form. The dissolution studies showed good masking properties of microparticles with Eudragit E 100. Expert Opin Drug Deliv. Banana and peanut butter. It has been surprising discovered that rum ether provides an extremely effective anti-bitter mask for oral prednisolone, that is far superior to other anti-bitter masking compositions. masking the bitter taste of prednisolone and fast disintegrating tablets can be suggested as a promising choice for use in patients who have problems with swallowing bitter taste drugs. As their votes are tallied, we ask our family physicians-in-training to brainstorm ways parents can deal with bad-tasting medicines. I don’t know if this has ever happened to anyone else but I either taste prednisone, or it tastes like I have just eaten a bowl of sugar by itself. Amelian A, Wasilewska K, Wesoły M, Ciosek-Skibińska P, Winnicka K. Saudi Pharm J. Rum ether is preferably present in an amount of from about 0.001:1 to about 0.1:1 weight ratio amount of rum ether to prednisolone sodium phosphate, with a more preferred range of from about 0.01:1 to about 0.1:1 weight ratio of rum ether to prednisolone sodium phosphate. Orodispersible films were prepared by casting polymeric solutions of hydroxypropyl methylcellulose containing uniformly dispersed microparticles. … Suitable coloring agents for use in pharmaceutical solutions are well known in the art. You can get super hungry! Recent Formulation Advances and Therapeutic Usefulness of Orally Disintegrating Tablets (ODTs). Masking the taste of different active ingredients in a compounded medication is an experience that can be very difficult and frustrating. The Anointing Oil Exodus Refer To Hemp Prednisolone And Cbd Hemp Oil (15) The Anointing Oil Exodus Refer To Hemp Square Hemp Oil (1) The Anointing Oil Exodus Refer To Hemp Hemp Oil To Heal Penis (3) The Anointing Oil Exodus Refer To Hemp Suzie S Hemp Oil (2) The Anointing Oil Exodus Refer To Hemp Hemp Oil Cold Pressed Taste (4) Int J Mol Sci. Flu vaccine for people who are pregnant. One of the main issues related to their preparation is an efficient taste masking of a bitter drug substance. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Introduction. You know what they say..."a spoonful of sugar helps the medicine go down..." Rum ether is preferably present in an amount of from about 0.001:1 to about 0.1:1 weight ratio amount of rum ether to prednisolone sodium phosphate, with a more preferred range of from about 0.01:1 to about 0.1:1 weight ratio of rum ether to prednisolone sodium phosphate. Having young doctors taste each one helps them remember to avoid using liquid prednisone and order prednisolone liquid instead. Presently preferred sweetener includes partially hydrolyzed starch or corn syrup. Crush and Mix in Food. Have glass of water ready Spoon pill into mouth and take swallow of water Down the hatch No ugly taste and I'm ready for the second pill. The typical active daily dose of the prednisolone sodium phosphate depends on various factors such as, for example, the individual requirement of each patient, the route of administration, and the disease. Among them complex prepared from β-cyclodextrin in weight ratio 1:4 was optimized basis on taste panel evaluation and drug release from complex. One of the main issues related to their preparation is an efficient taste masking of a bitter drug substance. Steroid medications like dexamethasone and prednisone -- which are anti-inflammatory and suppress the immune system -- make sense in that scenario, according to … 4.0 grams of prednisolone sodium phosphate were then added and mixed until dissolved. However, prednisolone has a bitter taste which is difficult to moderate. Preservatives may be included in a given pharmaceutical formulation of the present invention as appropriate, with preferred amounts of up to 1 gram per 100 mL of the solution. The composition is useful in numerous forms of the prednisolone, including refrigerated and non-refrigerated prednisolone pharmaceutical solutions and pediatric formulations. An aqueous pharmaceutical prednisolone composition of the present invention was formulated by preparing a mixture of hydroxyethylcellulose dissolved in 500 milliliters of purified water with 5 mL of rum ether, with potassium phosphate dibasic and potassium phosphate monobasic added (from a hot water mixture). Patients on corticosteroids are more susceptible to infections and can develop more serious infections than healthy individuals. 2. I am going to mix the chocolate milk and make him a milk shake. The doctor prednisolone buy in canada may be involved, so hard lenses, and leukocytosis; steroids and don't rely on improving coronary vessels visible? Please enable it to take advantage of the complete set of features! Prednisone is a glucocorticoid. 2020 Dec 15;250:117012. doi: 10.1016/j.carbpol.2020.117012. Coloring agents also may be incorporated in the solution of the present invention as determined by one skilled in the art to be appropriate, for chemical compatibility with other ingredients in the solution and the like. Carbohydr Polym. More than half of these pediatric patients experience an asthma exacerbation each year. When my son has to take prednisolone I sandwich the dose between teaspoons of honey and graham crackers. Depending upon the active substance used and upon the amount of active substance present in a particular device according to the present invention, a unit dose may comprise one or more such devices. Prednisolone and other corticosteroids can mask signs of infection and impair the body's natural immune response to infection. The prednisolone composition of the present invention may include any appropriate dosage form for the administration of prednisolone having the need for taste masking of the prednisolone active agent, such as chewable, aqueous and solid oral formulations, and combinations thereof. How To Mask Prednisolone Taste Buy Cheap Generics Online. Fixed oils, such as almond, peanut, sesame, olive and corn oil, are often necessary in preparations in which the stability of the drug is … Epub 2014 Feb 5. Abstract. Felicity Payne was a keen walker who like running after her five grandchildren See, for example, Fenaroli's Handbook of Flavor Ingredients, 4th Edition, edited by George A. Burdock, Ph.D., CRC Press, 2002, pp. It also gives a unique identity to a product and thereby provides a competitive advantage to a company, especially in the case of over-the-counter products. Therefore, the aim of this study was to prepare and evaluate the microparticles intended to mask a bitter taste of the prednisolone and use them in further preparation of two orodispersible dosage forms. The amount of prednisolone released after first 3 min of the dissolution test was below the estimated threshold described in the literature. Pharmacy (Basel). The amount of sugar sweetener used in the solution varies with the degree of sweetening desired for the particular formulation as determinable by one skilled in the art, with preferred amounts of sugar sweetener ranging from about 0 grams to about 100 grams sugar sweetener per 100 mL of the solution, more preferably from about 20 grams to about 95 grams per 100 mL of solution, still more preferably from 30 grams to about 90 grams sugar sweetener per 100 mL of the solution, and most preferably from about 40 grams to about 85 grams per 100 mL of solution. The precise amount of sweetening and/or flavoring agent(s) depends on the properties of the agent(s) used, however generally in an amount that is sufficient to mask the bitter taste associated with prednisolone as determinable by one skilled in the art. However, almost 4 years later, my Rheumy is currently treating my osteo with painkillers as now I am on 3g of pred my osteo pain is considerably worse. Additionally, a pH adjusting composition may be used to further adjust the pH of the composition, with pH adjusting compositions readily known in the art. CONTACT US . By the term “effective dosage”, it is understood that, with respect to, for example, pharmaceuticals, a pharmaceutically effective amount is contemplated. Techniques and methods for evaluating preservative efficacy in a given pharmaceutical formulations are readily known in the art. These types of steroids are different to the anabolic steroids abused by body builders or athletes wishing to gain a competitive edge. COVID-19 is an emerging, rapidly evolving situation.  |  sstevens23. Effect of solvents and cellulosic polymers on quality attributes of films loaded with a poorly water-soluble drug. The different tastes of … The aim of the present study was to formulate a taste-masked orally disintegrating tablet of prednisolone for pediatric and geriatric use. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Prednisolone sodium phosphate is a known active pharmaceutical ingredient (API) in medication regulated by the U.S. Food & Drug Administration (FDA). Prednisone is a corticosteroid - often called a steroid for short. 2020 Dec 31;15(12):e0244646. One of the main issues related to their preparation is an efficient taste masking of a bitter drug substance. As described herein, the preferred embodiment the present invention includes prednisolone sodium phosphate and rum ether in combination with appropriate excipients for the administration of the prednisolone. All rights reserved. Coloring agents are generally used to provide an appealing color to the solution. It has a boiling point of between 65° C. and 87° C. and a density of 0.825 g/mL at 25° C. It has been known since the 1910s, and has been used as an artificial rum flavoring component, in beverages, candy and ice cream. Orally disintegrating dosage forms and taste-masking technologies; 2010. Representative suitable flavoring agents may be for example, without limitation, menthol, cinnamon, wintergreen, clove, bay, anise, eucalyptus, thyme, cedar leave, nutmeg, sage, bitter almonds and cassia, vanilla, artificial vanilla, chocolate, artificial chocolate, bubble gum, both natural and artificial fruit flavors, such as cherry flavor, grape flavor, orange flavor, strawberry flavor, lemon flavor, grapefruit flavor and “mint” flavors such as peppermint flavor and spearmint flavor, lime flavor, apple flavor, pear flavor, peach flavor, raspberry flavor, plum flavor, pineapple flavor, apricot flavor and so forth, including combinations of two or more thereof. In addition, chill the medication to help reduce the unflattering taste. Taste is a crucial factor that determines the palatability of oral dosage form and patient compliance. The foregoing summary, description, and examples of the invention are not intended to be limiting, but are only exemplary of the inventive features which are defined in the claims. For instance, chickenpox and measles viruses can produce serious and even fatal illnesses in patients on high doses of prednisolone. Flavoring agents are generally provided as a minor component of the solution in amounts effective to provide a palatable flavor to the solution. Yes it is a liquid form. As if you don’t eat something or anything soon you will lose it!It hit me all of a sudden right around 4 a.m. when I should have been sleeping! Of these, the aqueous oral formulation is best administered as a rum ether taste-masked active pharmaceutical ingredient. & C. dyes and natural coloring agents such as grape skin extract, beet red powder, beta-carotene, annato, carmine, turmeric, paprika, combinations thereof and other such materials known to those skilled in the art. Medications such as Prednisolone, Prednisone and Dexamethasone are used to treat a variety of disorders, but unfortunatey due to bitter taste, are very difficult for young patients to swallow. The appreciable biological response may occur as a result of administration of single or multiple unit doses of an active substance. ABSTRACT: Asthma affects approximately one in 10 children in the United States. The dose of prednisolone that Group A will receive will be 1-2mg/kg/day for 7 days and then the dose will be slowly reduced and then stopped after 3 weeks. This site needs JavaScript to work properly. An improved taste-masked pharmaceutical prednisolone composition contains prednisolone sodium phosphate taste-masked with an effective taste-masking amount of rum ether. 2015 Apr;41(4):540-51. doi: 10.3109/03639045.2014.884122. 2014 Oct;9(10):1109-20. doi: 10.1517/17460441.2014.941802. Reply to Family Physician's Post: He is over 3 1/2 years old. Preferably, sodium hydroxide is used. Taste-masked prednisolone oral formulations (PAT - US2006127472) ' ' WHITEHEAD ... -06-15. A pharmaceutically effective dosage is the amount or quantity of a drug or pharmaceutically active substance which is enough for the required or desired therapeutic response, or in other words, the amount, which is sufficient to elicit an appreciable biological response when, administered to a patient. It is used to treat conditions such as arthritis, blood problems, immune system disorders, skin and eye conditions, breathing problems, cancer, and severe allergies. When present, preferably the cellulose derivative is present in an amount of up to about 50 grams of cellulose derivative per liter of solution, with preferred ranges of from about 0.5 grams to about 40 grams of cellulose derivative per liter of solution, more preferably from about 1 gram to about 25 grams of cellulose derivative per liter of solution, and most preferably from about 1.5 grams to about 10 grams of cellulose derivative per liter of solution. Components of rum ether are generally described as at least 99% water, ethyl alcohol, ethyl acetate, methanol, ethyl formate, acetone, acetaldehyde and formaldehyde, with methanol and formaldehyde contents not exceeding 5%. These results indicate that the taste of prednisolone and quinine is stronger or more bitter than that of caffeine as expected. With the aim to maximize prednisolone therapeutic action allowing the right timing of glucocorticoid therapy, different engineered microparticles (gel-beads) were manufactured using prilling (laminar jet break-up) as micro-encapsulation technique and Zn-alginate as gastroresistant carrier. Representative buffering agents of the present invention include, without limitation, potassium dihydrogen orthophosphate, disodium hydrogen orthophosphate, disodium hydrogen orthophosphate, potassium phosphate, potassium phosphate monobasic, potassium phosphate dibasic, sodium phosphate monobasic, sodium phosphate dibasic, potassium metaphosphate, citric acid, monobasic sodium acetate and sodium citrate anhydrous and dehydrate and other such like materials known in the art, and combinations thereof. It is supposed to be taken with food anyway, and I find that the honey + cracker makes a coating on his tongue so that he can't taste the medicine as much. In present research work an attempt was made to develop and evaluate orodipersible taste masked prednisolone sodium phosphate by direct compression method and by using cross povidone, cross carmellose sodium and sodium starch glycolate as superdisintegrants. Prednisolone oral formulations are prescribed pharmaceutical dosages used for treatment of endocrine disorders, rheumatic disorders, dermatologic diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, nervous system conditions and other conditions. I realized it also had a bit of a dusting on it from the pill bottle so I started gently wiping off the pills before I took them and that helped with both of them. A metallic taste in the mouth can be caused by certain medications such as some antibiotics, prenatal vitamins and antidepressants, as well as some medications used to treat high blood pressure, rheumatoid arthritis or kidney stones. developments of taste-masking techniques are of great significance in improving their organoleptic properties. Taste-masking assessment of orally disintegrating tablets and lyophilisates with cetirizine dihydrochloride microparticles. Corticosteroids come in two types - glucocorticoids and mineralocorticoids. 2020 Jul 22;12(8):692. doi: 10.3390/pharmaceutics12080692. Suitable flavoring agents include natural and artificial flavors, such as synthetic flavor oils and flavoring aromatics and/or natural oils, extracts from plants, leaves, flowers, fruits and so forth and combinations thereof. USA.gov. i also chug a ton of water and take a bite of fruit or something after I take it. To camouflage the bitter taste of medicine, crush or empty out capsules and mix them into small amounts of food. eCollection 2020. For example, prednisolone sodium phosphate is chemically known as pregna-1,4-diene-3,20-dione, 11,17-dihydroxy-21-(phosphonooxy)-, disodium salt, (11b). Fouad SA, Malaak FA, El-Nabarawi MA, Abu Zeid K. PLoS One. 1601-1602 and Encyclopedia of Food and Color Additives, edited by George A. Burdock, Ph.D., Volume III, P-Z, CRC press 1997, pp. The formulation uses a taste-masking ingredient of rum ether to overcome the bitter taste of the prednisolone. The present invention includes an improved taste-masked pharmaceutical prednisolone composition that includes prednisolone taste-masked with an effective taste-masking amount of rum ether. Copyright © 2015 Elsevier B.V. All rights reserved. Prednisolone liquid tastes bitter but liquid prednisone tastes even WORSE. I still would love to know an eaiser way to get this down him. Cut a small piece of a Medjool date (a raisin will work if your tabs are small enough) and flatten it between your fingers. These aqueous compositions or formulations of prednisolone sodium phosphate generally have uniformly dispersed mixtures at the molecular or ionic level of solute, which includes prednisolone sodium phosphate, rum ether, and appropriate excipients such as those detailed herein, mixed in a primary solvent of water. I still would love to know an eaiser way to get this down him. 75% better in 24hours. generation, LIPOSOMAL REDUCED GLUTATHIONE AND 1-ARGININE, INCLUDING WITH OTHER INGREDIENT(S), CAPABLE OF MULTIPATH ADMINISTRATION FOR REVERSAL AND PREVENTION OF OBESITY AND FOR MITOCHONDRIAL BIOGENESIS, Pharmaceutical compositions comprising mycophenolic acid or mycophenolate salt, Immunoconjugates with improved efficacy for the treatment of diseases, SKELETAL MUSCLE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF, AGENT FOR INHIBITING PRODUCTION OF HEPATITIS C VIRUS AND ITS USE, ADHERENCE INHIBITOR DIRECTED TO AND METHOD OF MAKING AND USING, Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy, Compositions and methods for stabilizing active pharmaceutical ingredients. Make sure to measure out the correct dose of your medicine. Click for automatic bibliography prednisolone composition prednisolone acetate diseases Prior art date 2005-08-04 Legal status (The legal status is an assumption and is not a legal conclusion. As the relative amount of prednisolone sodium phosphate is increased within a given volume of solution, such as over about 20 grams of prednisolone sodium phosphate per liter, the solution becomes increasing problematic to readily taste-mask. Microparticles; Oral thin film; Orally disintegrating tablet; Orodispersible film; Orodispersible tablet; Taste-masking. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. This article reviews the … The amount of buffering agent possibly included in the formulation includes appropriate amounts as determinable by one skilled in the art of prednisolone oral formulations. Thank you for your help. Feasibility of Assessing Lymphoma Response to Precise Local Injection of Candidate Chemotherapy Agents - Full Text View. Glucocorticoids have a powerful anti-inflammatory effect and mimic cortisol (a … This article reviews the concept of perception of taste, various taste masking techniques available, selection of appropriate taste masking technique, and evaluation tests for taste masking. In one preferred embodiment of the present invention as an oral formulation, the aqueous formulation may comprise prednisolone sodium phosphate dissolved in purified water, an effectively stabilizing amount of rum ether, a preservative and sweetener, with the pH of the aqueous formulation moderated by the use of appropriate pH adjusting compositions. Here is an easy way to bypass the awful taste of prednisone. Methods: Granulation and microencapsulation were used as methods for coating the drug particles with taste masking polymers. Usually fruit juices work best for this because they have strong tastes that can overwhelm the taste of the medicine. As described herein, the preferred embodiment the present invention includes prednisolone sodium phosphate and rum ether in combination with appropriate excipients for the administration of the prednisolone. Ask pharmacist about availability of flavoured medicine. prednisolone prednisolone acetate suspension Prior art date 2005-08-04 Legal status (The legal status is an assumption and is not a legal conclusion. Variations and adjustments of the pH of the aqueous formulation is preferably obtained by moderating the addition of the buffer salt(s) and pH adjusting composition(s). Keywords: Optimal Design, Characterization and Preliminary Safety Evaluation of an Edible Orodispersible Formulation for Pediatric Tuberculosis Pharmacotherapy. Objectives: To determine whether significant differences exist in the taste, texture, smell, and aftertaste of three commonly used liquid steroid preparations: prednisone, prednisolone, and dexamethasone. Ask us questions, inquire about our services or schedule a “lunch and learn” seminar about the art and science of taste masking. Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug for enhanced dissolution: In-vitro optimization/in-vivo evaluation. Guhmann M, Preis M, Gerber F, Pöllinger N, Breitkreutz J, Weitschies W. Drug Dev Ind Pharm. It was probably the effect of faster microparticles wetting in orodispersible forms and their partial destruction by compression force during tableting process. Therefore, the aim of this study was to prepare and evaluate the microparticles intended to mask a bitter taste of the prednisolone and use them in further preparation of … There are several taste masking techniques available, which either involve modification of bitter active pharmaceutical ingredient itself or the formulation. The phrase “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with tissues of human beings and animals and without excessive toxicity, irritation, allergic response, or any other problem or complication, commensurate with a reasonable benefit/risk ratio. Additional preservatives useful in the present invention include, but are not limited to, sodium benzoate, potassium sorbate, salts of edetate (also know as salts of ethylenediaminetetraacetic acid, or EDTA, such as disodium edetate) and antimicrobial agents including parabens (p-hydroxybenzoic acids esters) such as methylparaben, ethylparaben, propylparaben, butylparaben and the like. How inhalers could make your 'asthma' WORSE and why they may also mask an equally serious condition. Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing. However, flavoring agents are generally present in the solution in amounts in the range of from about 0 grams to about 10 grams per 100 mL of the solution, with preferred amounts of from about 2 grams to about 5 grams per 100 mL. Use a Straw. As such, there is a need in the art to provide a superior taste-masked prednisolone oral dosage form. 2017 Dec;25(8):1144-1150. doi: 10.1016/j.jsps.2017.06.001. Oil-based liquids help mask bitter tasting drugs by providing a coating that protects the taste buds from the sensation of bitterness. The pharmaceutical formulation of the present invention preferably contains flavoring agents (herein referred to also as “flavorants”), sweetening agents, and combinations thereof to mask the inherently bitter taste associated with prednisolone, and thereby improving the palatability of the solution of the present invention.  |  Of these, the aqueous oral formulation is best administered as a taste-masked active pharmaceutical ingredient. La prednisolona es un glucocorticoide ampliamente utilizado en la mayoría de las situaciones infla- Senopsys LLC 800 West Cummings Park Suite 1500 Woburn, MA 01801 … The amount of therapeutic compound incorporated in each device of the present invention will be at least one or more dosage form and can be selected according to known principles of pharmacy. Masking of bitter taste of prednisolone was carried out using techniques like preparation of solid dispersion with PEG 6000, complex formation with Indion-204 resin and β-cyclodextrin. I had metallic taste particularly when attempting to drink alcohol, wine and beer, as soon as starting on 15mg Pred for PMR. The next facet of development was to assess the pharmacokinetics (PK) and relative bioequivalence (BE) of prednisone from this new formulation. HHS As used herein, the term “treatment”, or a derivative thereof, contemplates partial or complete inhibition of the stated disease state such as, for example, endocrine disorders, rheumatic disorders, dermatologic diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, nervous system conditions and other conditions, when an active ingredient of the present invention is administered prophylactically or following the onset of the disease state for which such active ingredient of the present invention is administered. A more preferred range is from about 5 mg to about 25 mg total daily dose, and a most preferred range is from about 10 mg to about 20 mg total daily dose, such as about 15 mg. Evaluation of Chlorpheniramine Maleate microparticles in orally disintegrating film and orally disintegrating tablet for pediatrics. The formulation uses a taste-masking ingredient of rum ether to overcome the bitter taste of the prednisolone. Sweeteners suitable for inclusion in the present invention may be determined by one skilled in the art including, for example without limitation, both natural and artificial sweeteners such as the representative sweetening agents of intense sweeteners such as sorbitol, sucrose, saccharins such as sodium saccharin, cyclamates such as sodium cyclamates, aspartame, sucralose, thaumatin, acesulfam K, and the like, and sugars such as monosaccharides, disaccharides and polysaccharides.

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